Comment: Barbiturates may increase adverse effects, such as respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
pentobarbital increases effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers may boost metabolism of ifosfamide to its metabolite. Watch for increased effects/toxicities if merged with CYP2B6 inducers.
pentobarbital will lessen the level or effect of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
pentobarbital will minimize the level or outcome of finasteride by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital will decrease the extent or result of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated. Coadministration of doravirine with a strong CYP3A inducer may possibly decrease doravirine plasma concentrations and/or effects. Opportunity for loss of virologic response and doable resistance to doravirine.
Monoamine oxidase inhibitors check here (MAOI) may perhaps inhibit barbiturate metabolism and prolong barbiturate effects; keep an eye on intently
Contraindicated (1)pentobarbital will minimize the level or impact of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Observe INR additional usually if coadministered with inducers of these isoenzymes and regulate warfarin dose if essential.
Remark: Barbiturates may perhaps maximize adverse effects, including respiratory despair, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
When the buprenorphine dose is insufficient plus the CYP3A4 inducer can't be reduced or discontinued, transition the client again to your buprenorphine formulation that permits dose adjustments.
pentobarbital will lessen the extent or influence of amiodarone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will decrease the extent or impact of ketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will reduce the extent or influence of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.